Xeomin® and Gait Related Mobility After Stroke

Recruiting now · Phase 4

Conditions studied: Stroke

In brief

The aim of the present pilot study is to evaluate the association between change in gait related mobility in ambulatory male and female adult hemiparetic patients before and 4-6-weeks after Xeomin® injection into the upper limb, using two standardized tests of physical function in outpatient rehabilitation that are widely used; the 10-meter walk test and the timed 'up and go' test (TUG).

Key facts

Study ID

NCT04908423

Run by

Wake Forest University Health Sciences

People needed

20

Starts

2021-10-19

Expected to finish

2027-04-01

Last updated by the study team

2025-11-25

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of hemiparesis and spasticity secondary to stroke with upper and lower limb spasticity and unilateral motor and/or sensory deficit
• No prior surgery to the lower limb
• Able to walk at least 10 meters without physical assistance from another person and without an assistive device
• Toe- ground clearance during swing phase without assistive device or orthoses
• No treatment with botulinum toxin within the past 4 months

You may not qualify if…

• Passive range of motion at either the ankle, knee, or elbow joint less than 30 degrees
• Participants with uncorrected hearing impairment
• Weight bearing restrictions due to concurrent orthopedic injuries that would make ambulating with or without an assistive device unsafe
• Speech language expression deficit (e.g., aphasia)
• Absence of proprioception upon neurologic examination
• Presence of fixed contractures in the upper or lower extremities not correctable to neutral
• Other confounding neurological diagnoses or active acute illness (cancer, Parkinson's disease, multiple sclerosis)

Where it is running

• Carolinas Rehabilitation — Charlotte, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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