A Trial of Pharmacist Management of Oral Anticoagulation THerapy in the communitY for AF

Completed · Phase 4

Conditions studied: Atrial Fibrillation, Stroke

In brief

This is a prospective, single-arm, feasibility pilot study of 20 participants (aged 60 years or older, with additional stroke risk factors and 'actionable' undertreated AF) recruited from a total of 4 retail and outpatient community pharmacies. Eligible participants will be enrolled in a 3-month active intervention of pharmacist-led OAC management. Participants will be passively followed for an additional 9 months to determine safety endpoints.

Key facts

Study ID: NCT04907825
Run by: Cedars-Sinai Medical Center
People needed: 14
Starts: 2023-03-13
Expected to finish: 2026-01-31
Last updated by the study team: 2026-08-10

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Age > 60 years
Men (CHADS-VASc score ≥2) AND Women (CHADS-VASc score ≥3)
AF and not on OAC therapy but eligible
AF and on sub-optimal or inappropriate OAC therapy
Written informed consent

You may not qualify if…

AF on optimal OAC therapy
OAC required for other conditions (i.e. DVT/PE, PCI in prior year, left ventricular thrombus, etc.)
Currently taking two antiplatelet agents
Uncontrolled hypertension (defined as SBP ≥160 mmHg x 2 BP readings measured at screening)
End-stage renal disease (CrCl <15 ml/min or dialysis)
Major surgery in prior month (defined as surgery requiring general anesthesia and overnight inpatient hospital stay)
History of "major bleeding" in prior year (defined as overt bleeding at critical site including intracranial, intraspinal, intraocular, pericardial, GI bleed, bleed requiring hospitalization, bleed resulting in ≥20 g/L drop in hemoglobin or requiring transfusion of ≥2 units packed cells)
Excess alcohol intake (≥8 alcoholic drinks/week)
Inability to read or understand English or Spanish
Participants considered unreliable by the Investigator or designated pharmacy team member concerning the requirements of follow-up, or those with foreshortened life expectancy precluding 3-month follow-up
Severe cognitive impairment (≥5 errors on the Short Portable Mental Status Questionnaire)
Pregnant women

Where it is running

Cedars-Sinai Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.