Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion

Completed · Not applicable

Conditions studied: Anterior Cruciate Ligament Injuries, Exercise, Cartilage, Articular, Knee Injuries, Osteoarthritis, Osteoarthritis, Knee, Arthritis, Joint Diseases

In brief

Osteoarthritis (OA) is a leading cause of disability worldwide that affects millions of Americans each year. Posttraumatic OA (PTOA) significantly impacts patients after anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) with approximately 50% of patients developing PTOA within 20 years of injury or surgery. Knee joint mechanical loading measured via physical activity (i.e. daily steps) is insufficient in individuals after ACLR compared to uninjured individuals. Establishing the beneficial effects of physical activity to promote optimal free-living knee joint mechanical loading and improve knee joint health will aid in the development of cost-effective interventions that prevent PTOA and health burden of the disease.

Key facts

Study ID

NCT04906499

Run by

University of North Carolina, Chapel Hill

People needed

7

Starts

2021-08-01

Expected to finish

2022-09-09

Last updated by the study team

2024-01-29

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants will be included if they:
• Provide informed consent and sign a HIPPA form prior to any study procedures are performed
• Have completed all other formal physical therapy and therapeutic exercise regimens, and will not be engaging in any other formal therapy for their ACLR during the study
• Are between the ages of 18 and 35.
• Underwent an ACLR no earlier than 6 months and no later than 5 years prior to enrollment.
• Demonstrate < 8,000 steps per day during the screening phase of the study as assessed using the Actigraph GT9X Link monitor.
• Demonstrate clinically relevant-knee symptoms, defined as a Knee Injury and Osteoarthritis Outcomes Score (KOOS) quality of life subscale < 72.2

You may not qualify if…

• Participants will be excluded if:
• The participant underwent an ACLR revision surgery due to a previous ACL graft injury.
• Multiple ligament surgery was indicated at the time of ACLR surgery.
• A lower extremity fracture was suffered during the ACL injury.
• The participant has been diagnosed with osteoarthritis in either knee
• They have a cochlear implant, metal in body, claustrophobia, or history of seizures.

Where it is running

• Fetzer Hall, University of North Carolina — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.