Vfib by ECG or Echo During Cardiac Arrest

Completed

Conditions studied: Cardiac Arrest

In brief

The goal of this study is to measure survival rates associated with patients presenting in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm. Electrocardiographic rhythm is defined as the rhythm on the ECG and echocardiographic rhythm is the rhythm visualized on bedside ultrasound. Specifically, we will categorize patients based on identical rhythms and dichotomous rhythms with an interest in outcomes in the patient group where their echocardiographic and electrographic rhythms do not match. This is important as current ACLS protocols use electrocardiographic rhythms to determine therapy but limited research implies that therapeutic decisions based on echocardiographic rhythm may produce increased survival. This study will occur during emergency department resuscitation of patients presenting in cardiac arrest. Patients presenting to the emergency department after cardiac arrest will undergo standard resuscitation based on ACLS protocols. Ultrasound imaging will be performed as soon as possible after the patient arrives and digitally recorded, as is currently the standard of care at the institute. Simultaneous recording of the ECG rhythm strip will occur as well. This will be repeated for as many pauses in CPR as is warranted. Each site will record data based on the Utstein nomenclature including patient demographics, arrest details and survival outcomes. Ultrasound images and ECG recordings will be de-identified and submitted to a central database. Data will be uploaded into a centralized database. Statistical analysis will analyze outcomes based on echocardiographic and sonographic findings. Our aim is to measure the survival benefit of treating out of hospital cardiac arrest using echocardiographic rhythm instead of electrocardiographic rhythm.

Key facts

Study ID

NCT04906252

Run by

Romolo Gaspari

People needed

813

Starts

2021-09-15

Expected to finish

2025-01-01

Last updated by the study team

2025-04-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients presenting in out-of-hospital, atraumatic cardiac arrest

You may not qualify if…

• Resuscitation ended due to end of life decisions
• Documented allergy to ultrasound gel
• Technical malfunction of ultrasound machine during imaging that prevents use Ultrasound machine unable to record images

Where it is running

• Hartford Hospital — Hartford, Connecticut, United States
• Dartmouth Hitchcock Medical Center — Lebanon, New Hampshire, United States
• Stony Brook University — Stony Brook, New York, United States
• Duke University — Durham, North Carolina, United States
• Allegheny Hospital — Pittsburgh, Pennsylvania, United States
• Univesity of Texas San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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