HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide
Running, not enrolling · Phase 2
Conditions studied: Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia, Chronic Lymphocytic Leukemia, Lymphoma
In brief
This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. Post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate mofetil (MMF) will be used for for graft versus host disease (GVHD) prophylaxis. This trial will study how well this treatment works in patients with hematologic malignancies.
Key facts
- Study ID
- NCT04904588
- Run by
- Center for International Blood and Marrow Transplant Research
- People needed
- 300
- Starts
- 2021-09-30
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-03-18
Who can join
Age: 1 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- City of Hope National Medical Center — Duarte, California, United States
- University of California San Francisco — San Francisco, California, United States
- Stanford University — Stanford, California, United States
- Colorado Blood Cancer Institute — Denver, Colorado, United States
- University of Florida Health Shands Hospital — Gainesville, Florida, United States
- University of Miami Sylvester Cancer Center — Miami, Florida, United States
- H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
- Children's Healthcare of Atlanta — Atlanta, Georgia, United States
- Emory University Medical Center — Atlanta, Georgia, United States
- Northwestern University — Chicago, Illinois, United States
- The University of Chicago — Chicago, Illinois, United States
- University of Maryland Medical Center — Baltimore, Maryland, United States
- The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- University of Michigan Medical Center - Mott Children's Hospita — Ann Arbor, Michigan, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- Mayo Clinic Rochester — Rochester, Minnesota, United States
- Washington University/Barnes Jewish Hospital — St Louis, Missouri, United States
- Roswell Park Comprehensive Cancer Center — Buffalo, New York, United States
- Columbia University Medical Center — New York, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- University of North Carolina Chapel Hill — Chapel Hill, North Carolina, United States
- Cincinnati Children's Hospital — Cincinnati, Ohio, United States
- Ohio State Medical Center, James Cancer Center — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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