Absorption and Safety of Topical Timolol to Treat Chronic Wounds
Completed
Conditions studied: Glaucoma, Open-Angle, Chronic Wounds
In brief
Topical timolol has been used primarily as eye drops to treat glaucoma for many years. Recent clinical experience has broadened its off-label use for a number of skin conditions, including slow-healing wounds. While there have been extensive safety studies performed on timolol administration to treat the eye, to date, no studies have documented absorption of timolol after applied on chronic wounds. Thus, the purpose of this study is to determine the blood levels of timolol in patients after topical administration to a chronic wound, and compare these levels with those of patients after administration of the same drug formulation on the eye for the indication of glaucoma.
Key facts
- Study ID
- NCT04903366
- Run by
- VA Northern California Health Care System
- People needed
- 40
- Starts
- 2017-11-21
- Expected to finish
- 2020-01-14
- Last updated by the study team
- 2021-05-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Over 18 years of age
- Using physician-prescribed timolol as directed
- The ability to read, understand, and sign informed consent for blood draw and release of medical information forms
- For wound group: documented chronic wound (greater than 30 days, with minimal improvement), with any type of wound.
- For glaucoma group: diagnosed with ocular hypertension or open-angle glaucoma.
You may not qualify if…
- Patient is not currently prescribed timolol or currently taking oral metoprolol
- History of any type of heart block
- History of bradycardia (heart-rate less than 60 beats per minute (bpm))
- History of documented hypotension
- History of asthma or chronic obstructive pulmonary disease.
Where it is running
- VA Northern California Health Care System — Mather, California, United States
Full record on ClinicalTrials.gov
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