HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma
Running, not enrolling · Phase 1
Conditions studied: Ependymoma
In brief
This is a Phase I study to evaluate the safety profile of a type of immune therapy called HER2 CAR T cells (short for HER2 chimeric antigen receptor T cells). In addition to looking for side effects, we will study how well this treatment works against a brain tumor called ependymoma that has come back after treatment (recurrent) or has not responded well to treatment (progressive) in children. The HER2 CAR T cells used in this trial are made from the patient's own blood. A new gene, called the HER2 CAR, will be inserted into patient's T cells to allow them recognize a protein on the tumor called HER2. These HER2-specific CAR T cells may be able to target and kill ependymoma tumors that express HER2. This research is also studying how doable it is to provide this type of CAR T cell treatment to children being treated at different hospitals.
Key facts
- Study ID
- NCT04903080
- Run by
- Children's Oncology Group
- People needed
- 50
- Starts
- 2022-07-27
- Expected to finish
- 2033-03-31
- Last updated by the study team
- 2026-06-02
Who can join
Age: 1 and older, up to 22. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Children's Hospital Los Angeles — Los Angeles, California, United States
- Children's Hospital Colorado — Aurora, Colorado, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- University of Florida — Gainesville, Florida, United States
- Children's Healthcare of Atlanta — Atlanta, Georgia, United States
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Nationwide Children's Hospital — Columbus, Ohio, United States
- Pittsburgh Children's Hospital of UPMC — Pittsburgh, Pennsylvania, United States
- Texas Children's Cancer Center — Houston, Texas, United States
- The Hospital for Sick Children — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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