Circadian Rhythms in Postmenopausal Women

Recruiting now · Not applicable

Conditions studied: Metabolic Syndrome, Postmenopausal Symptoms

In brief

This is a randomized, parallel two-arm clinical trial design to study the efficacy of time-restricted feeding on metabolic risk in postmenopausal women, who may be particularly vulnerable to disruption of circadian eating rhythms and the associated metabolic dysfunction. It is hypothesized that time-restricted feeding will improve insulin sensitivity, glucose tolerance, body weight, and other metabolic parameters in metabolically-unhealthy postmenopausal women.

Key facts

Study ID

NCT04893226

Run by

Julie Pendergast

People needed

164

Starts

2021-10-19

Expected to finish

2027-01-31

Last updated by the study team

2026-08-10

Who can join

Age: 45 and older, up to 65. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• postmenopausal women
• age 45-65 years
• prediabetic or have at least 2 features of metabolic syndrome

You may not qualify if…

• on hormone therapy
• diabetes
• heart disease
• alcohol consumption of >2 drinks per day
• significant circadian disruption
• having care-taking responsibilities that significantly affect sleep
• shift work or irregular lifestyle
• uncontrolled sleep apnea or other uncontrolled sleep disorder
• extreme early or late chronotypes
• significant psychiatric disorders
• taking ADHD medications
• diagnosed dysregulated eating behaviors
• smoking >5 cigarettes/day or 30 pack-year history
• participating in formal weight loss program
• not weight stable

Where it is running

• University of Kentucky — Lexington, Kentucky, United States (enrolling)

Full record on ClinicalTrials.gov

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