Vestibular Precision: Physiology & Pathophysiology
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Vestibular Schwannoma, Inner Ear Disease, Dizziness, Neurofibromatosis 2, Vestibular Disorder
In brief
This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors. The investigators will study vestibular precision in normal subjects and patients with peripheral vestibular damage, and will investigate its potential plasticity. The goals are to develop a better understanding of the role noise plays in the vestibular system in normal and pathologic populations, and to determine if the brain can learn to improve signal recognition within its inherently noisy neural environment, which would result in improved behavioral precision.
Key facts
- Study ID
- NCT04890132
- Run by
- Massachusetts Eye and Ear Infirmary
- People needed
- 90
- Starts
- 2020-07-01
- Expected to finish
- 2025-06-30
- Last updated by the study team
- 2023-03-16
Who can join
Age: 8 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Normal subjects:
- normal vestibular-oculomotor exams
- normal low-frequency standard rotational testing
- normal hearing
- Vestibular Schwannoma:
- existence of unilateral vestibular schwannoma (pre \& post surgical resection)
- must have sub-occipital surgical approach with complete sectioning of the vestibular nerve
- rotational testing to assess pre-surgical vestibular function
- audiogram
- brain MRI consistent with vestibular schwannoma
- audiography in each ear
You may not qualify if…
- Normal subjects
- history of otologic or neurologic disease
- on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic)
- Vestibular Schwannoma
- other otologic disease (other than presbycusis) or any neurologic disease (other than migraine)
- on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic)
Where it is running
- Massachusetts Eye and Ear Infirmary — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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