Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy

Running, not enrolling · Not applicable

Conditions studied: Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm

In brief

This phase II trial studies whether using exercise is better than the usual approach for treating chemotherapy-induced peripheral neuropathy (CIPN). CIPN occurs when chemotherapy damages the nerves communicating between the brain, spinal cord, and the rest of the body. The usual approach for treating CIPN is treatment with drugs that help reduce symptoms of other types of neuropathy (for example, from diabetes). However, these drugs do not treat all symptoms of CIPN. Exercise may help to reduce CIPN symptoms.

Key facts

Study ID

NCT04888988

Run by

University of Rochester NCORP Research Base

People needed

133

Starts

2022-02-25

Expected to finish

2026-06-30

Last updated by the study team

2026-04-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a diagnosis of cancer
• Have received neurotoxic chemotherapy within the past nine months (could still be on chemotherapy or have already completed chemotherapy; i.e., taxane-, platinum-, vinca alkaloid-, epothilone-, or proteasome inhibitor-based chemotherapy
• Report one or more symptoms of CIPN at a level of >= 4 on the CIPN symptom inventory on the Screening Form
• Have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
• Have at least six months life expectancy
• Be at least 18 years of age
• Be able to read and understand English
• Be able to provide written informed consent

You may not qualify if…

• Have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in a low to moderate intensity home-based walking and progressive resistance exercise program, according to the participant's physician (e.g., oncologist, primary care) or physician's designee
• Be identified as in the active or maintenance stage of exercise behavior per the Exercise Stages of Change Question on the Screening Form
• Have planned surgery or radiation treatment during the course of the study (hormonal and biologic therapy is allowed)
• Have contraindications for MRI scanning, per the MRI safety screening procedures of the MRI facility to be utilized for this participant
• Are pregnant of have plans to become pregnant during the course of the study. Documentation of pregnancy and use of contraception can be obtained from the medical record.
• Have a current or prior cancer in the central nervous system (spine, brainstem, brain) as this would interfere with assessments of brain functional connectivity.

Where it is running

• Contra Costa Regional Medical Center — Martinez, California, United States
• Kaiser Permanente-Roseville — Roseville, California, United States
• Kaiser Permanente Downtown Commons — Sacramento, California, United States
• Kaiser Permanente-South Sacramento — Sacramento, California, United States
• Kaiser Permanente-Santa Teresa-San Jose — San Jose, California, United States
• Kaiser Permanente San Leandro — San Leandro, California, United States
• Kaiser San Rafael-Gallinas — San Rafael, California, United States
• Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California, United States
• Kaiser Permanente-South San Francisco — South San Francisco, California, United States
• Kaiser Permanente-Vallejo — Vallejo, California, United States
• Kaiser Permanente-Walnut Creek — Walnut Creek, California, United States
• Rocky Mountain Cancer Centers-Aurora — Aurora, Colorado, United States
• Boulder Community Foothills Hospital — Boulder, Colorado, United States
• Rocky Mountain Cancer Centers-Boulder — Boulder, Colorado, United States
• Rocky Mountain Cancer Centers - Centennial — Centennial, Colorado, United States
• The Women's Imaging Center — Denver, Colorado, United States
• Colorado Blood Cancer Institute — Denver, Colorado, United States
• Rocky Mountain Cancer Centers-Midtown — Denver, Colorado, United States
• Rocky Mountain Cancer Centers-Rose — Denver, Colorado, United States
• Rocky Mountain Cancer Centers - Swedish — Englewood, Colorado, United States
• The Melanoma and Skin Cancer Institute — Englewood, Colorado, United States
• Rocky Mountain Cancer Centers-Lakewood — Lakewood, Colorado, United States
• Rocky Mountain Cancer Centers-Littleton — Littleton, Colorado, United States
• Rocky Mountain Cancer Centers-Sky Ridge — Lone Tree, Colorado, United States
• Kaiser Permanente-Fresno — Fresno, California, United States

Full record on ClinicalTrials.gov

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