68Ga-HA-DOTATATE Imaging of Suspected Somatostatin Receptor Positive Tumors

Recruiting now · Phase 2

Conditions studied: Neuroendocrine Tumors

In brief

Somatostatin receptor (SSR) imaging is a critical component of clinical care for many patients being investigated for or with confirmed SSR positive tumors. In the past, 111In-octreotide imaging has been used for this purpose but it has been recently supplanted globally by SSR positron emission tomography (PET) imaging due to better image quality and higher diagnostic accuracy. This study will assess the safety and diagnostic effectiveness of 68Ga-HA-DOTATATE produced a the Edmonton Radiopharmaceutical Centre (ERC).

Key facts

Study ID

NCT04888481

Run by

University of Alberta

People needed

600

Starts

2022-02-15

Expected to finish

2028-08-31

Last updated by the study team

2026-05-11

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with known or clinically suspected somatostatin receptor positive tumors including but not limited to: gastrointestinal neuroendocrine tumors, pancreatic neuroendocrine tumors, pulmonary neuroendocrine tumors, neuroendocrine tumors - primary unknown, pheochromocytoma, paraganglioma, medullary thyroid cancer, medulloblastoma, meningioma
• A standard clinical CT or MRI is obtained within 6 months of enrollment
• Ability to provide written informed consent prior to participation in the study (participant or if required a legal medical decision maker)

You may not qualify if…

• Weight > 225 kg (weight limit of the PET/CT scanner)
• Inability to scan (ie. extreme claustrophobia) or inability to lie still for imaging
• Any additional medical condition, serious inter-current illness, or other extenuating circumstance that, in the opinion of the investigator or attending department physician, may significantly interfere with study performance or interpretation
• Previous allergic reaction to DOTATATE or somatostatin analogues
• Lack of intravenous access

Where it is running

• University of Alberta — Edmonton, Alberta, Canada (enrolling)

Full record on ClinicalTrials.gov

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