Improving Diagnostic Accuracy for Acute Heart Failure

Completed

Conditions studied: Acute Heart Failure, Dyspnea, Dyspnea; Cardiac

In brief

Acute heart failure is a common reason for emergency department visits and hospitalization, but the diagnosis can be challenging because of non-specific symptoms and signs. The current diagnostic approach to acute heart failure has modest accuracy, leading to delayed diagnosis and treatment, which associate with worse prognosis. Prior work suggests diagnostic accuracy can be improved with the addition of multiple circulating biomarkers discovered through proteomics, and this study will derive and validate a multi-marker model to improve diagnostic accuracy for acute heart failure in the emergency department.

Key facts

Study ID

NCT04886128

Run by

Vanderbilt University Medical Center

People needed

2469

Starts

2021-08-31

Expected to finish

2026-05-01

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Willing to adhere to the study protocol
• Able to provide written consent
• English or Spanish speaking
• Adult, defined as 18 years or older
• Primary reason for presentation to the ED is dyspnea
• ED physician is considering a diagnosis of HF, defined by ordering a NP test and/or a chest x-ray

You may not qualify if…

• History of end-stage renal disease for which hemodialysis is needed
• Dyspnea due to primary presentation of an acute coronary syndrome or trauma

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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