Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language comprehension, cognitive control, and related attention and memory processes). Behavioral and electrophysiological (EEG) measures will be used to assess cognitive performance. Our overarching hypothesis is that stimulating prefrontal circuits with tDCS can improve cognitive control performance, and ultimately performance on a range of cognitive tasks, as compared to stimulating a different cortical region (occipital cortex) or using sham stimulation. This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.

Key facts

Study ID

NCT04885322

Run by

University of California, Davis

People needed

75

Starts

2021-04-14

Expected to finish

2027-06-30

Last updated by the study team

2025-12-05

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• between ages of 18 and 50
• ability to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks
• ability to give valid informed consent

You may not qualify if…

• no history of head trauma
• no current or previous history of treatment with psychotropic medication
• corrected vision 20/30 or better
• tDCS/MRI contraindications, including: pregnancy, ferrous metal in any part of the body, serious medical conditions, claustrophobia, metallic implants, skin damage, conditions such as eczema at electrode sites, cranial pathologies

Where it is running

• Imaging Research Center — Sacramento, California, United States (enrolling)

Full record on ClinicalTrials.gov

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