Preventing Prescription Stimulant Diversion and Medication Misuse Via a Web-Based Simulation Intervention
Completed · Not applicable · Has a placebo group
Conditions studied: Prescription Drug Abuse (Not Dependent), Intentional Misuse
In brief
Half or nearly half of college students with prescriptions divert their stimulant medication, and a similarly high percentage misuse their medication or use someone else's prescription. Diversion may lead students to go without needed medication to mitigate their symptoms, increasing their risk for unintentional injuries and substance use. Further, diversion perpetuates the non-medical use of prescription stimulants (NMUPS), which has become increasingly common among college students. Diversion also perpetuates medical misuse of stimulants among students with prescriptions, which is associated with poorer attention-deficit/hyperactivity disorder (AD/HD) symptom management and may increase the risk for addictive disorders. There are no evidence-based interventions targeting diversion of stimulants in college students. Being approached for one's medication is a key risk factor for diversion, as is medication non-adherence and believing NMUPS and diversion are more prevalent than they are. Accordingly, in this multi-site study, the investigators will conduct a randomized, controlled trial of 300 college-attending adults with current stimulant prescriptions to examine the preliminary efficacy and feasibility of a single-session, computer-based simulation intervention (with two booster sessions) to prevent prescription stimulant diversion and medication misuse and compare it to a placebo condition. The intervention, which is grounded in social learning theory and the theory of planned behavior uniquely engages students in interactive discussions with virtual humans to (a) learn about the actual prevalence of NMUPS and diversion and their related risks, (b) practice using refusal strategies when approached for their medication in high-risk situations, and (c) understand how to effectively communicate with prescribers and avoid medication misuse. The primary aims are to determine if the intervention reduces diversion, intentions to divert, and medication misuse, and to assess user satisfaction with the intervention. The secondary aims are to examine change in potential mechanisms of action targeted in the intervention, such as self-efficacy to resist diversion, knowledge about diversion and NMUPS, use of behavioral strategies to resist requests for one's medication, and prescriber communication. If effective, the intervention could be readily and widely disseminated to college counseling centers, psychiatrists, pediatricians, and other prescribers.
Key facts
- Study ID
- NCT04885166
- Run by
- Trinity College
- People needed
- 249
- Starts
- 2021-05-04
- Expected to finish
- 2024-05-21
- Last updated by the study team
- 2026-04-08
Who can join
Age: 17 and older, up to 25. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Undergraduate or graduate student at Trinity College (CT); University of Wyoming; Texas State University.
- Will be enrolled at Trinity College (CT); University of Wyoming; Texas State University 6-months from their baseline study session.
- Have a recent (within the past 3 months) prescription for a stimulant medication
- Between the ages of 17 and 25.
You may not qualify if…
- None.
Where it is running
- Trinity College — Hartford, Connecticut, United States
- Texas State University — San Marcos, Texas, United States
- University of Wyoming — Laramie, Wyoming, United States
Full record on ClinicalTrials.gov
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