CBD, Immune Function, and Neural Health
Completed · Not applicable · Has a placebo group
Conditions studied: Healthy
In brief
Chronic inflammation, which is defined as a persistent, low-grade inflammatory response within the body, is associated with many of the negative health conditions which are prevalent in our society today. It is most well-known for its role in the progression of diseases including obesity, metabolic syndrome, cancer, cardiovascular disease, and diabetes. Chronic inflammation is also linked to many of the underlying factors associated with disease development including perturbations in sleep, and mental health status such as depression, anxiety, fatigue, and quality of life. Natural killer cells, commonly referred to as NK cells, are a subset of white blood cells that play an important role in the coordination of inflammation in the body. Although many interventions aimed at controlling chronic inflammation and enhancing NK cell number and activity have been explored, relatively few have been administered without significant barriers. Cannabidiol (CBD), a non-psychoactive hemp derivative, is a potential, attractive therapeutic target. However, there is very little information in humans that addresses the potential of CBD to improve your health and immune function. The overall goal of this study is to explore the effects of 8-weeks of CBD supplementation on mental and physical health, sleep measures, and NK cell number and cytotoxic function. Specific Aim 1. Explore the effect of 8-weeks of CBD administration on sleep measures as well as measures of mental and physical health in conjunction with measurements of NK cell number and function.
Key facts
- Study ID
- NCT04881539
- Run by
- University of Northern Colorado
- People needed
- 50
- Starts
- 2021-05-15
- Expected to finish
- 2022-03-18
- Last updated by the study team
- 2022-03-31
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants must be within 18 and 50 years of age
- Abstained from cannabis (either THC and/or CBD) for the past 6 weeks
- Have a BMI of 29.9 or below
- Completes at least 150 minutes of moderate to vigorous physical activity per week.
- Able and willing to commit to an 8-week intervention schedule
You may not qualify if…
- Significant cardiovascular disorders including but not limited to serious arrhythmias, cardiomyopathy, congestive heart failure, stroke, or transient ischemic attacks, peripheral vascular disease with intermittent claudication, acute, chronic or recurrent thrombophlebitis.
- Diagnosed neurological disorders including but not limited to brain tumors, brain injuries, Alzheimer's Disease, Parkinson's Disease, multiple sclerosis, epilepsy, and seizures.
- Regular use of drugs that significantly alter brain activity such as selective serotonin reuptake inhibitors, benzodiazepines, and others used to treat anxiety, panic, stress, sleep disorders, or increases the risk of sedation and drowsiness.
- Head trauma with loss of consciousness for more than 30 mins.
Where it is running
- University Of Northern Colorado — Greeley, Colorado, United States
Full record on ClinicalTrials.gov
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