Overture Metabolomics Non-Selection Study

Status unconfirmed

Conditions studied: Infertility

In brief

In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening. Metabolomics is a new, non-invasive method of embryo selection which involves testing discarded embryo culture media for analytes secreted by the developing embryo. These analytes can be used to determine the implantation potential, and ploidy, of the embryo. This study will take place at multiple locations in the United States and Spain.

Key facts

Study ID

NCT04878991

Run by

Overture Life

People needed

410

Starts

2021-05-05

Expected to finish

2024-01-30

Last updated by the study team

2023-11-14

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women of any age, including egg donors. 50% will be <35 and the rest 35 and older.
• Signed Subject Consent Form. No inferior limit on number of eggs

You may not qualify if…

• At the time of initial visit:
• Require or request PGT of any kind
• Low ovarian reserve defined as follicle stimulating hormone (FSH) >10 IU/L on day 2-4 of a prior menstrual cycle and anti-mullerian hormone (AMH) <15 pmol/L (or <2 ng/ml) within prior 12 months of cycle start
• At the time of embryo selection:
• Patients without at least one embryo to transfer.

Where it is running

• New Hope Fertility Center — New York, New York, United States (enrolling)
• Clinical Juana Crespo — Valencia, Spain (enrolling)

Full record on ClinicalTrials.gov

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