Phenotype, Genotype and Biomarkers 2

Running, not enrolling

Conditions studied: Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, Progressive Muscular Atrophy, Frontotemporal Dementia

In brief

The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA) and multisystem proteinopathy (MSP). More precisely, the investigator wants to identify the links that exist between the disease phenotype (phenotype refers to observable signs and symptoms) and the disease genotype (genotype refers to your genetic information). The investigator also wants to identify biomarkers of ALS and related diseases.

Key facts

Study ID

NCT04875416

Run by

University of Miami

People needed

217

Starts

2021-01-08

Expected to finish

2031-09-01

Last updated by the study team

2026-06-15

Who can join

Age: 7 and older. Sex: any. Healthy volunteers: accepted.

Where it is running

• University of Miami — Miami, Florida, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Cape Town — Cape Town, South Africa

Full record on ClinicalTrials.gov

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