Taurine Effect on Glycemic, Lipidic and Inflammatory Profile in Individuals With Type 2 Diabetes
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Diabetes Mellitus, Type 2
In brief
Type 2 diabetes mellitus (DM2) is characterized by chronic hyperglycemia, which is a risk factor for comorbidities and death. Although conventional pharmacotherapy is effective, some individuals do not reach the glycemic targets, requiring adjuvant therapies. Taurine is a semi-essential amino acid with antioxidant and osmoregulatory properties, commonly used as a nutritional supplement. Pre-clinical studies show its effectiveness in reducing blood glucose and cholesterol, but there are no well-conducted clinical studies evaluating the effect of taurine on glycated hemoglobin. Additionally, animal models showed that taurine had a protective effect from diabetic nephropathy. The hypothesize of this study is that taurine administration improves the glycemic, lipid, inflammatory, and anthropometric parameters in DM2 individuals.
Key facts
- Study ID
- NCT04874012
- Run by
- Hospital de Clinicas de Porto Alegre
- People needed
- 94
- Starts
- 2021-06-12
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2025-09-19
Who can join
Age: 30 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Female and male individuals, with clinical diagnosis of DM2 for at least 6 months;
- Age over 30 years;
- BMC equal to or above 18.5 kg/m2, without weight change in the last 3 months;
- HbA1c between 7.5% and 10.5%.
You may not qualify if…
- Use of herbal supplements, antioxidants, and multivitamins in the last 3 months;
- Pregnancy or lactation;
- Chronic renal failure with glomerular filtration rate calculated by MDRD < 30 mL/h;
- Myocardial infarction in the last than 6 months
- Current neoplasia;
- Chronic use of glucocorticoids;
- Bariatric surgery.
Where it is running
- Hospital de Clínicas — Porto Alegre, Rio Grande do Sul, Brazil (enrolling)
Full record on ClinicalTrials.gov
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