Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Schizophrenia, Cannabis-Induced Disorder
In brief
Cannabis use disorder is a frequent comorbidity of schizophrenia, associated with increased symptoms and less adherence to therapy. Validated care has limited effectiveness in this population and development of new management strategies seems necessary. Transcranial direct current stimulation (tDCS) has shown beneficial effects in both schizophrenia, substance use disorder and, in a less extent, in nicotine addiction in schizophrenic subjects. It is interesting to test if that 10 sessions of anodal stimulation of the right dorsolateral prefrontal cortex (DLPFC) and cathodal stimulation of the medial prefrontal cortex (MPFC) (by increasing control and modulating reward system), will reduce, in 110 schizophrenic subjects, cannabis consumption, and secondly craving, addiction severity, schizophrenic symptoms and improve global functioning. It is possible that these clinical effects will be associated with changes in certain cognitive functions and cerebral connectivity.
Key facts
- Study ID
- NCT04871048
- Run by
- Centre Hospitalier Universitaire de Saint Etienne
- People needed
- 110
- Starts
- 2023-02-15
- Expected to finish
- 2030-06-30
- Last updated by the study team
- 2026-05-06
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Schizophrenia diagnostic according to DSM (Diagnostic and Statistical Manual of mental disorder) 5 criteria, without change in psychotropic treatment since at least 4 weeks
- Moderate to severe cannabis use disorder according to DSM 5 criteria and active consumption during the last 7 days
- Subjects motivated to reduce or quit their cannabis consumption
- Patients with ambulatory compulsory care may be included
You may not qualify if…
- Other substance use disorder, excluding nicotine, according to DSM 5 criteria
- Other current psychiatric disorder according to DSM 5 criteria, excluding personality disorder
- Inpatient hospitalization
- History of head injury, neurological disorder with cerebral consequence or severe unstable somatic disorder
- Pregnancy or no contraception
- Contraindications for tDCS and/or MRI (implanted material, uncontrolled epilepsy, intracranial hypertension)
Where it is running
- CHU de Saint-Etienne — Saint-Priest-en-Jarez, France (enrolling)
- Centre Hospitalier Universitaire Service d'Addictologie et Pathologies Duelles — Clermont-Ferrand, France
- CHU de Clermont-Ferrand Service de Psychiatrie — Clermont-Ferrand, France
- Service Hospitalo-Universitaire d'Addictologie CHU de Dijon — Dijon, France
- CH Le Vinatier Service universitaire d'addictologie de Lyon — Bron, France
- CH Saint-Cyr-au-Mont-d'Or service de psychiatrie — Saint-Cyr-au-Mont-d'Or, France
- Centre Hospitalier Alpes Isère — Saint-Égrève, France
- CHU Pôle de Psychiatrie Neurologie et Rééducation — La Tronche, France
Full record on ClinicalTrials.gov
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