An Alternative Way To Deliver Oxygen To People
Withdrawn before enrolling · Early Phase 1
Conditions studied: Hypoxia
In brief
The availability of oxygen is a crucial prognostic indicator for outcomes pertinent to many chronic diseases. Accordingly, interventions that might increase oxygen availability have obvious beneficial clinical application. In this regard, Respirogen Micro-Oxygen (RMO) technology holds considerable promise. Data from experimental animal models of lung injury suggest administration of RMO is a feasible method to deliver oxygen in a manner independent of pulmonary function. Our ultimate long-term goal is to provide a product that can be used to deliver oxygen to humans experiencing respiratory distress and pulmonary dysfunction In this first exploratory study, our goal is to begin to understand the physiological responses to enteral (rectal) delivery of RMO in low-oxygen environments in healthy adults at rest.
Key facts
- Study ID
- NCT04870801
- Run by
- Christopher Bell
- People needed
- 0
- Starts
- 2022-01-01
- Expected to finish
- 2024-01-01
- Last updated by the study team
- 2022-06-30
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- age between 18-40 years,
- body mass index between 19 and 30 kg/m\^2,
- resident at a similar altitude for a minimum of 1-year,
- no travel to/from areas varying by \~2000 feet of elevation within 4-weeks of initiation of study participation.
You may not qualify if…
- identification of overt chronic disease (including cardio-pulmonary disorders),
- prior diagnosis of asthma, cystic fibrosis, Chronic obstructive pulmonary disease, or ventilator therapy
- anemia,
- pregnancy,
- habitual use of tobacco/nicotine products,
- known allergy to sodium phosphate (or other common laxatives),
- habitual use of recreational drugs that require inhalation,
- history of seizures, kidney problems, stomach or bowel problems, ulcerative colitis, problems with swallowing or gastric reflux, gout, and and/or low blood sodium.
- irritable bowel
- ACUTE respiratory illness such as bronchitis, pneumonia, Upper Respiratory Infection OR ACUTE GI issues such as gastroenteritis.
- Anemia (as measurement of hemoglobin and/or hematocrit) .
- sickle cell disease.
- history of altitude sickness
Where it is running
- Colorado State University, Dept. of Health and Exercise Science — Fort Collins, Colorado, United States
Full record on ClinicalTrials.gov
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