Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)
Enrolling by invitation
Conditions studied: Sarcopenia
In brief
The goal of the proposed research is to investigate Magnetic Resonance (MR) Fingerprinting and P-MRS (Phosphorus-31 MR Spectroscopy) imaging for characterization of skeletal muscle in heart failure patients with sarcopenia. Heart failure patients with and without sarcopenia will be scanned using MR Fingerprinting and an existing Post-exercise phosphocreatine (PCr) recovery MR imaging protocol to obtain characteristic profiles of quantitative T1, T2, and PCr recovery rate.
Key facts
- Study ID
- NCT04869813
- Run by
- The Cleveland Clinic
- People needed
- 70
- Starts
- 2021-04-09
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-06-25
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Heart failure patients
- Age ≥40 yrs
- Stable chronic heart failure
- Systolic dysfunction determined by cardiac MRI with left ventricle ejection fraction 40% or less
- Healthy Volunteers
- Age ≥40 yrs
- No diagnosed heart failure or sarcopenia
You may not qualify if…
- Heart failure patients
- Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease
- Healthy volunteers (controls)
- Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease
- Contraindications to MRI Contraindications to MRI
- Heart pacemaker/defibrillator
- Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires
- Cochlear implant or other ear implants
- Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity)
- Programmable shunt
- Aneurysm clips and coils
- Stents
- Filters (for example, blood clot filters)
- Metal fragment in body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings)
Where it is running
- Cleveland Clinic — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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