Magnetic Imaging for Diagnostic of Amyotrophic Lateral Sclerosis

Recruiting now · Not applicable

Conditions studied: Amyotrophic Lateral Sclerosis With Dementia

In brief

Nearly 60% of Amyotrophic Lateral Sclerosis (ALS) patients have a low level of diagnostic certainty (possible, probable) at the time of diagnosis. In the absence of biomarkers, this diagnosis is based, among other things, on the demonstration of the diffusion of signs of denervation by electroneuromyography (ENMG). The objective of this study is to improve the earliness and the level of diagnostic certainty by better demonstrating the diffusion of the denervation process by whole body muscular MRI.

Key facts

Study ID

NCT04868994

Run by

University Hospital, Toulouse

People needed

50

Starts

2021-06-01

Expected to finish

2024-12-01

Last updated by the study team

2024-08-02

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Consent form signed by the patient
• Patients suspected ALS defined according Awaji Shima criteria (possible, probable, defined)
• Clinical assessment of upper motor neuron involvement
• Electrophysiologic assessment of lower motor neuron involvement

You may not qualify if…

• inability to give informed consent
• a contraindication to MRI
• respiratory failure impairing ability to lie flat in the scanner.
• Patient placed under judicial protection or under another protective regime,
• Females who are pregnant

Where it is running

• Pascal CINTAS — Toulouse, France (enrolling)

Full record on ClinicalTrials.gov

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