Heterotopic Ossification Prophylaxis

Completed · Not applicable

Conditions studied: Acetabular Fracture, Heterotopic Ossification

In brief

One complication that can occur after surgery on the acetabulum is the development of bone in abnormal places such as muscle and soft tissues. There is some evidence that a single dose of radiation to the surgical site within 3 days of surgery will prevent this abnormal bone from forming. However, there are no high quality studies proving that radiation works any better than doing nothing at all. The purpose of our study is to determine whether there is a difference in abnormal bone formation after acetabular surgery when patients are treated with external beam irradiation versus no treatment.

Key facts

Study ID

NCT04867278

Run by

University of Maryland, Baltimore

People needed

117

Starts

2021-05-09

Expected to finish

2023-12-31

Last updated by the study team

2024-12-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult aged 18+ with an acute acetabular fracture
• Indicated for surgical fixation via a posterior or combined anterior and posterior approach

You may not qualify if…

• Contraindication to radiotherapy such as history of cancer/RT
• Patients that are getting an acute total hip arthroplasty at the time of fixation of the acetabular fracture
• Not English speaking
• Not a Maryland resident or likely to have difficulty returning for post-op follow up(s) (i.e. homeless, incarceration)

Where it is running

• University of Maryland, Shock Trauma Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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