Memantine Augmentation of Targeted Cognitive Training in Schizophrenia
Completed · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Schizophrenia, Schizoaffective Disorder
In brief
Treatment of schizophrenia currently includes antipsychotic medications and cognitive therapies which improve some symptoms, but do not sufficiently restore cognitive functioning or reduce psychosocial disability. We hypothesize that medications that specifically target sensory information processing deficits, rather than psychotic symptoms per se, will significantly enhance the benefits of a sensory-based targeted cognitive training (TCT) intervention in patients with schizophrenia. We will complete a randomized, double-blind clinical trial to: 1) confirm that the drug memantine augments TCT learning; 2) determine whether memantine enhances the clinical benefits from a full 30 session course of TCT vs. TCT plus placebo in antipsychotic- medicated schizophrenia patients, and 3) determine if memantine's enhancement of TCT is most effective in biomarker-defined subgroups of patients.
Key facts
- Study ID
- NCT04857983
- Run by
- University of California, San Diego
- People needed
- 62
- Starts
- 2021-07-06
- Expected to finish
- 2025-03-30
- Last updated by the study team
- 2026-05-18
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- DSM-IV diagnosis of schizophrenia or schizoaffective disorder
- Written informed consent to participate in the study
- Age 18-65
- Absence of dementia or mental retardation
- Urine toxicology negative for recreational drugs
- Fluent and literate in English
You may not qualify if…
- Meets DSM-IV criteria for current substance abuse or dependence and has been substance abstinent for less than 30 days
- A history of traumatic brain injury
- Auditory or visual impairments severe enough to prevent study participation
- Under conservatorship (determined by Anasazi)
- Pregnancy
Where it is running
- Clinical Teaching Facility (CTF B-403 at UCSD Medical Center) — San Diego, California, United States
Full record on ClinicalTrials.gov
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