NEUROIMAGING OF ADOLESCENT BORDERLINE PERSONALITY DISORDER WITH AND WITHOUT POST-TRAUMATIC STRESS DISORDER

Recruiting now · Not applicable

Conditions studied: Borderline Personality Disorder

In brief

Borderline personality disorder (BPD) is a common mental disorder in adolescents with significant individual and societal repercussions, characterized over the long term by emotional hyperresponsiveness, relational instability, identity disturbances and self-aggressive behavior. The etiology of BPD is multifactorial and involves exposure to traumatic life events, which are present in the majority of cases. This explains the very common co-morbidity between BPD and post-traumatic stress disorder (PTSD), which involves emotionally painful memory relapses of one or more traumatic events, associated with an emotional trauma avoidance syndrome (s). ) and hypervigilance. Brain imaging studies in adolescents with BPD have shown decreases in the volume of gray matter within the frontolimbic network, as well as a decrease in frontolimbic white matter bundles. These brain changes are considered to be biological markers of TPB. However, the exact same brain changes are seen in PTSD. Although it represents more than a third of adolescents hospitalized in psychiatry, neuroscientific studies of BPD in adolescence are still scarce. The expertise we have acquired in U1077 in adolescents with PTSD offers us an exceptional opportunity to characterize in BPD with and without PTSD structural anomalies, including the hippocampus, and functional at rest, never used for hour in the teenager's BPD. Beyond that, carrying out an 18-month follow-up of the patients will allow us to assess the predictive value of these anomalies on the level of general psychopathology in all the patients studied and the intensity of the symptoms of traumatic relapse in the patients with PTSD. This modeling of disorders integrating psychopathological, neuropsychological and neuroanatomical approaches will provide the clinician with new knowledge necessary for therapeutic innovation.

Key facts

Study ID

NCT04852744

Run by

University Hospital, Caen

People needed

99

Starts

2022-03-11

Expected to finish

2028-06-01

Last updated by the study team

2025-07-25

Who can join

Age: 13 and older, up to 18. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• For the 3 groups:
• female
• Age between 13 and 17 years inclusive
• Oral and written comprehension of the French language
• Affiliation to the social security scheme
• Informed consent signed by the legal representatives holding the exercise of parental authority and the adolescent herself
• For patients:
• Diagnosis of borderline personality disorder according to the criteria of the Diagnostic and Statistical Manual for mental disorders, fifth edition (DSM-5; American Psychiatric Association, 2013; SIDP-IV)
• Level of general psychopathology compatible with participation in the study (score> 20 on the CGA-S)
• TB + / PTSD + group:
• Post-traumatic stress disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL)
• In the control group :
• Absence of mental disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL and SIDP-IV)
• Oral and written comprehension of the French language
• Informed consent signed by the legal representative, the holder (s) of the exercise of parental authority and the adolescent herself

You may not qualify if…

• - Illiteracy / illiteracy
• Sensory disorder (visual, auditory)
• Severe chronic psychiatric comorbidity: autism spectrum disorder, intellectual disability, schizophrenia spectrum disorder and other psychotic disorders, bipolar disorder
• Severe or current brain pathology (chronic neurological disease, encephalitis, history of severe head trauma), alertness disorder
• History of anoxic coma
• Contraindication to MRI (magnetic foreign body, claustrophobia, contraindication to prolonged lying down)
• Severe physical pathology in progress
• Moving outside the Normandy region planned within 18 months
• The inclusion of the subject in another biomedical research protocol (during the present study)
• Intellectual deficit (IQ <70)
• Pregnant or breastfeeding women

Where it is running

• Caen University Hospital — Caen, France (enrolling)

Full record on ClinicalTrials.gov

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