Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy
Recruiting now · Not applicable
Conditions studied: Antithrombotic Therapy, Perioperative Care, Perioperative Outcomes
In brief
The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic antithrombotic therapy before surgery.
Key facts
- Study ID
- NCT04852406
- Run by
- Peking University First Hospital
- People needed
- 526
- Starts
- 2021-04-21
- Expected to finish
- 2026-01-01
- Last updated by the study team
- 2025-07-31
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1. Patients with continuing antithrombotic therapy (including antiplatelet and/or anticoagulant therapies) for cardiovascular and cerebrovascular diseases for more than 2 weeks.
- 2. Patients who have one or more of the following situations: (1) non-valvular atrial fibrillation with a CHA2DS2-VASc score >4; (2) post-artificial valve replacement (including mitral valve, ball-cage valve or tilting disc aortic valve); (3) venous thromboembolism occurred within 1 year, or venous thromboembolism with other high-risk factors which require long-term anticoagulation treatment; (4) coronary heart disease with coronary stent implantation, thrombolytic therapy or other coronary procedures within 2 years, or who had undergone coronary artery bypass grafting within 1 year, or who experienced myocardial infarction or acute coronary syndrome within 1 year; (5) a history of stroke/transient ischemic accident within 1 year, or a history of cervical or intracranial revascularization treatment within 1 year; (6) peripheral arterial disease.
- 3. Patients who are scheduled to undergo intra-abdominal surgery (including general and urologic surgery).
- 4. Patients who sign written informed consents.
You may not qualify if…
- 1. Refuse to participate.
- 2. Emergency surgery.
- 3. Unable to complete the preoperative assessment and follow-up plan.
- 4. Other reasons that are considered unsuitable for study participation by the investigators or the attending doctors.
Where it is running
- Peking University First Hospital — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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