Prospective Assessment of Impact of Personalized Dosing of Low-dose Human Chorionic Gonadotropin (hCG) on in Vitro Fertilization (IVF) Outcomes
Stopped early · Not applicable
Conditions studied: Infertility, Female
In brief
The purpose of the study is to determine the effect of tailoring dosage of low-dose hCG secondary to serum hCG levels during IVF ovarian stimulation on sustained implantation rates of preimplantation genetically tested euploid embryos.
Key facts
- Study ID
- NCT04852029
- Run by
- Reproductive Medicine Associates of New Jersey
- People needed
- 12
- Starts
- 2021-08-16
- Expected to finish
- 2021-12-31
- Last updated by the study team
- 2022-01-28
Who can join
Age: 18 and older, up to 46. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Patients whose physicians plan to prescribe low-dose hCG for ovarian stimulation
- Age 18-46
- Negative serum hCG prior to start of COH
- BMI >18 and <35
- Plan for ejaculated sperm use
- Plan for PGT testing with euploid embryo transfer
You may not qualify if…
- Administration of low-dose hCG during frozen embryo transfer cycle
- Concomitant Menopur administration during ovarian stimulation or during frozen embryo transfer cycle
- BMI <18 or >35
- Age <18 or >46
- Presence of hydrosalpinxes that communicate with the endometrial cavity
- Diagnosis of endometrial insufficiency: prior cycle with maximal endometrial thickness ≤ 6mm, abnormal endometrial pattern (failure to attain a trilaminar appearance), and persistent endometrial fluid
- Uncorrected uterine factor infertility (uterine anomaly, submucosal myomas, uterine septum)
- Male partner with <100,000 total motile spermatozoa per ejaculate (donor sperm is acceptable)
- Use of surgical procedures to obtain sperm
- Couples undergoing IVF for fertility preservation with no immediate plan for subsequent FET (embryo banking)
- Personal history of repeated pregnancy loss (two or more unexplained clinical losses defined by presence of fetal heartbeat)
- Declination of PGT testing
Where it is running
- Reproductive Medicine Associates of New Jersey — Basking Ridge, New Jersey, United States
Full record on ClinicalTrials.gov
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