A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With XLRP
Running, not enrolling · Phase 2/Phase 3
Conditions studied: X-Linked Retinitis Pigmentosa
In brief
This study will evaluate and compare the safety, efficacy, and tolerability of 2 doses of a recombinant adeno-associated virus vector (AGTC-501/laruparetigene zovaparvovec )) to an untreated control group in male participants with X-linked retinitis pigmentosa caused by RPGR mutations.
Key facts
- Study ID
- NCT04850118
- Run by
- Beacon Therapeutics
- People needed
- 85
- Starts
- 2024-03-14
- Expected to finish
- 2031-10-31
- Last updated by the study team
- 2026-04-07
Who can join
Age: 12 and older, up to 50. Sex: male. Healthy volunteers: not accepted.
Where it is running
- Retina Macula Institute of Arizona — Scottsdale, Arizona, United States
- Children's Hospital Los Angeles — Los Angeles, California, United States
- University of Florida Health Jacksonville, Department of Ophthalmology — Jacksonville, Florida, United States
- Bascom Palmer Eye Institute- University of Miami — Miami, Florida, United States
- Midwest Eye Institute (Retina Partners Midwest) — Carmel, Indiana, United States
- Wilmer Eye Institute at Johns Hopkins — Baltimore, Maryland, United States
- Ophthalmic Consultants of Boston — Boston, Massachusetts, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Duke Eye Center — Durham, North Carolina, United States
- Cincinnati Eye Institute — Cincinnati, Ohio, United States
- Cole Eye Institute - Cleveland Clinic — Cleveland, Ohio, United States
- Casey Eye Institute, OHSU — Portland, Oregon, United States
- The Center for Advanced Retinal & Ocular Therapeutics University of Pennsylvania Perelman School of Medicine — Philadelphia, Pennsylvania, United States
- Mid Atlantic Retina — Philadelphia, Pennsylvania, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- Retina Consultants of Texas — Bellaire, Texas, United States
- Retina Foundation of the Southwest — Dallas, Texas, United States
- Baylor Eye Institute — Houston, Texas, United States
- Retina Consultants of San Antonio Texas — San Antonio, Texas, United States
- Sydney Eye Hospital — Sydney, New South Wales, Australia
- Royal Victorian Eye & Ear Hospital — East Melbourne, Victoria, Australia
- McGill University Health Centre - Glen Site — Montreal, Quebec, Canada
- Moorfields Eye Hospital — London, United Kingdom
- The Retina Clinic London, Institute of Ophthalmology, University College London — London, United Kingdom
- Oxford Eye Hospital — Oxford, United Kingdom
Full record on ClinicalTrials.gov
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