Treatment Strategy to Enhance Nrf2 Signaling in Older Adults

Completed · Not applicable · Has a placebo group

Conditions studied: Aging Problems

In brief

Exercise is the cornerstone of disease prevention and often an important component of treatment. However, the efficacy of an exercise stimulus is reduced with aging. This study will investigate whether adding a treatment with phytonutrients found in cruciferous vegetables can improve the exercise response in older individuals.

Key facts

Study ID

NCT04848792

Run by

Northern Arizona University

People needed

32

Starts

2023-02-09

Expected to finish

2025-05-27

Last updated by the study team

2025-08-28

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women, 60 years and older
• Competent to independently give informed consent
• Successful completion of screening
• Maximal oxygen consumption below the 60th percentile based on gender:
• Women: ≤ 21.2 mL/kg/min
• Men: ≤ 30.5 mL/kg/min

You may not qualify if…

• Estrogen supplementation (in any form) within the previous 6 months
• Any medication that could affect outcome measures such as statins, blood pressure medications, or anti-depressives
• Use of anti-oxidant supplements, in excess of standard multi-vitamins (1 tablet/day) and/or any supplements known to target Nrf2 including resveratrol, Protandim, and sulforaphane
• Current smoker
• Body Mass Index (BMI) greater than 33 kg/m2 (Class I Obesity)
• Any chronic illness that could affect outcome measures, including diabetes, liver or renal disease, or cancer (other than skin cancer)
• History of a myocardial infarction within the last 6 months, clinically significant aortic stenosis, use of cardiac defibrillator, or uncontrolled angina
• Clinically significant arrhythmia on a resting EKG or significant EKG changes during the baseline VO2 max test
• Any other condition that would contraindicate maximal exercise testing, including elevated blood pressure at rest (systolic BP >150 or diastolic BP >90 mm Hg on at least 2 measurements, at least 10 minutes apart) or musculoskeletal problems

Where it is running

• Northern Arizona University — Flagstaff, Arizona, United States

Full record on ClinicalTrials.gov

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