A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer
Stopped early · Phase 1/Phase 2
Conditions studied: Squamous Cell Cancer of Head and Neck (SCCHN), Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer
In brief
The main aim of this study is to check for side effects and tolerability of TAK-186 (also known as MVC-101) in adults with unremovable advanced or metastatic cancer. Another aim is to characterize and evaluate the activity of TAK-186 (MVC-101). Participants may receive treatment throughout the study for a maximum of 13 months and will be followed up at 30 days and 90 days and then every 12 weeks for up to 48 weeks after the last treatment.
Key facts
- Study ID
- NCT04844073
- Run by
- Takeda
- People needed
- 95
- Starts
- 2021-03-08
- Expected to finish
- 2025-06-17
- Last updated by the study team
- 2025-12-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UC San Diego Moores Cancer Center — San Diego, California, United States
- University of California San Francisco — San Francisco, California, United States
- University of Colorado - Anschutz Medical Campus - PPDS — Aurora, Colorado, United States
- Yale University — New Haven, Connecticut, United States
- Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Northwestern University — Chicago, Illinois, United States
- Indiana University — Indianapolis, Indiana, United States
- University of Minnesota Medical Center, Fairview — Minneapolis, Minnesota, United States
- Columbia University Medical Center -161 Fort Washington — New York, New York, United States
- Novant Health Cancer Institute - Elizabeth Head and Neck — Charlotte, North Carolina, United States
- Sanford Cancer Center — Sioux Falls, South Dakota, United States
- Mary Crowley Cancer Research Centers Medical City - SCRI - PPDS — Dallas, Texas, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- Fred Hutchinson Cancer Research Center - 1100 Fairview Ave N — Seattle, Washington, United States
- Scientia Clinical Research Limited — Randwick, New South Wales, Australia
- Chris O'Brien Lifehouse Hospital — Sydney, New South Wales, Australia
- Southern Oncology Clinical Research — Bedford Park, South Australia, Australia
- Monash University - Australian Centre for Blood Diseases (ACBD) — Clayton, Victoria, Australia
- Avera Cancer Institute at Sioux Falls — Heidelberg, Victoria, Australia
- Paula Fox Melanoma and Cancer Centre — Melbourne, Victoria, Australia
- Severance Hospital Yonsei University Health System — Seoul, Seodaemun-Gu, South Korea
- Seoul National University Hospital — Seoul, Seoul Teugbyeolsi, South Korea
- Asan Medical Center — Seoul, Seoul Teugbyeolsi, South Korea
- Samsung Medical Center — Seoul, South Korea
Full record on ClinicalTrials.gov
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