Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)

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Conditions studied: Dry Eye, Neuropathic Pain

In brief

This study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.

Key facts

Study ID

NCT04838223

Run by

Tufts Medical Center

People needed

1000

Starts

2021-07-02

Expected to finish

2026-07-01

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Presents with ocular surface discomfort or for dry eye care
• Best corrected visual acuity of 20/40 or better in each eye
• Subject reported duration of symptoms of at least 3 months
• 100 subjects will be required to be habitual contact lens wearers as defined by use of contact lenses at least 5 hours per day at least 5 days per week for the last year.

You may not qualify if…

• Use of contact lenses on the day of the visit
• Pregnant or nursing
• Irregular corneas (e.g., ectatic disease, transplantation, or corneal dystrophies)
• Ocular surgery in the past 3 months
• Ocular infection in the past 3 months
• Active ocular allergies

Where it is running

• Canyon City Eye Care — Azusa, California, United States
• Western University of Health Sciences — Pomona, California, United States
• University of California at San Francisco - Francis I Proctor Foundation — San Francisco, California, United States
• Bruce W. Carter VA Medical Center — Miami, Florida, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• Illinois College of Optometry — Chicago, Illinois, United States
• Kannarr Eye Care — Pittsburg, Kansas, United States
• University of Maryland — Baltimore, Maryland, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• Korb & Associates — Boston, Massachusetts, United States
• Midwest Vision Research Foundation at Prepose Vision Institute — St Louis, Missouri, United States
• Ophthalmology Associates — St Louis, Missouri, United States
• Vita Eye Clinic — Shelby, North Carolina, United States
• SkyVision Centers — Westlake, Ohio, United States
• Hospital of the University of Pennsylvania (Scheie Eye Institute Perelman) — Philadelphia, Pennsylvania, United States
• Baylor College of Medicine — Houston, Texas, United States

Full record on ClinicalTrials.gov

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