ALPN-101 (Acazicolcept) in Systemic Lupus Erythematosus

Completed · Phase 2 · Has a placebo group

Conditions studied: Systemic Lupus Erythematosus

In brief

This is Phase 2, multinational, randomized, blinded study to evaluate the safety, tolerability, efficacy, immunogenicity, pharmacokinetics and pharmacodynamics of ALPN-101 (acazicolcept) in adults with moderate to severe active systemic lupus erythematosus (SLE)

Key facts

Study ID

NCT04835441

Run by

Alpine Immune Sciences Inc, A Subsidiary of Vertex

People needed

76

Starts

2021-06-22

Expected to finish

2024-07-09

Last updated by the study team

2025-08-15

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Investigational Site (107) — Anniston, Alabama, United States
• Investigational Site (189) — Phoenix, Arizona, United States
• Investigational Site (155) — Los Angeles, California, United States
• Investigational Site (109) — San Diego, California, United States
• Investigational Site (169) — Santa Barbara, California, United States
• Investigational Site (106) — DeBary, Florida, United States
• Investigational Site (120) — Hialeah, Florida, United States
• Investigational Sites (134) — Miami, Florida, United States
• Investigational Site (152) — Ormond Beach, Florida, United States
• Investigational Site (133) — Plantation, Florida, United States
• Investigational Site (190) — Tamarac, Florida, United States
• Investigational Site (163) — Tampa, Florida, United States
• Investigational Site (173) — Idaho Falls, Idaho, United States
• Investigational Site (156) — Skokie, Illinois, United States
• Investigational Site (138) — Grand Blanc, Michigan, United States
• Investigational Site (164) — Las Vegas, Nevada, United States
• Investigational Site (175) — Brooklyn, New York, United States
• Investigational Site (115) — Manhasset, New York, United States
• Investigational Site (179) — Charlotte, North Carolina, United States
• Investigational Site (112) — Crossville, Tennessee, United States
• Investigational Site (186) — Memphis, Tennessee, United States
• Investigational Site (171) — Baytown, Texas, United States
• Investigational Site (143) — Bellaire, Texas, United States
• Investigational Site (118) — Colleyville, Texas, United States
• Investigational Site (166) — Fort Worth, Texas, United States

Full record on ClinicalTrials.gov

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