ASL in Brain Metastasis MRI Following Gamma Knife Treatment

Recruiting now · Not applicable

Conditions studied: Brain Metastases

In brief

Arterial spin labeling (ASL) is a non-invasive MRI technique that could help the radiologists to distinguish brain metastasis progression versus radionecrosis following gamma-knife treatment. The primary target of the study is to establish the diagnostic performances (specificity, sensitivity) of quantitative measures of ASL in brain metastases suspected of progression/radionecrosis after GK treatment

Key facts

Study ID

NCT04833335

Run by

Assistance Publique - Hôpitaux de Paris

People needed

60

Starts

2023-01-24

Expected to finish

2028-09-24

Last updated by the study team

2025-08-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Brain metastasis from histologically proven tumor
• GK treatment within 4 month prior to the inclusion
• Lesions suspected of progression/ radionecrosis :
• i.e.≥ 25% of the size progression
• Lesion size: gadolinium enhanced part of the tumour ≥1 cm

You may not qualify if…

• Pregnancy
• Medical history of primitive brain tumour
• MRI incompatibility/ medical history of contrast agent allergy
• Claustrophobia
• Patient unable to consent
• Epilepsia/recent stroke
• Patients participating in other studies
• Patients without health care insurance

Where it is running

• Service de neuroradiologie, hôpital Pitié Salpêtrière — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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