A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer
Stopped early · Phase 2
Conditions studied: Non-Small Cell Lung Cancer (NSCLC)
In brief
This study will evaluate the surgical safety and feasibility of atezolizumab plus tiragolumab alone or in combination with platinum-based chemotherapy as neoadjuvant treatment for participants with previously untreated locally advanced non-small cell lung cancer (NSCLC). The study will also evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of atezolizumab plus tiragolumab alone or in combination with platinum-based chemotherapy as neoadjuvant treatment, followed by adjuvant atezolizumab plus tiragolumab or adjuvant platinum-based chemotherapy.
Key facts
- Study ID
- NCT04832854
- Run by
- Hoffmann-La Roche
- People needed
- 50
- Starts
- 2021-04-23
- Expected to finish
- 2025-03-05
- Last updated by the study team
- 2026-03-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- City of Hope Cancer Center — Duarte, California, United States
- University of Southern California — Los Angeles, California, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Winthrop Univ Hospital — Mineola, New York, United States
- NYU Cancer Center — New York, New York, United States
- Columbia University — New York, New York, United States
- Sunshine Coast University Hospital — Birtinya, Queensland, Australia
- Peter Maccallum Cancer Institute — Melbourne, Victoria, Australia
- St. Vincent's Hospital — Gyeonggi-do, South Korea
- Severance Hospital, Yonsei University Health System — Seoul, South Korea
- ICO L'Hospitalet — L'Hospitalet de Llobregat, Barcelona, Spain
- Corporacio Sanitaria Parc Tauli — Sabadell, Barcelona, Spain
- Hospital Universitario Puerta de Hierro — Majadahonda, Madrid, Spain
- Complejo Hospitalario Universitario A Coruña (CHUAC) — A Coruña, Spain
- Vall d?Hebron Institute of Oncology (VHIO), Barcelona — Barcelona, Spain
- Hospital Universitario 12 de Octubre — Madrid, Spain
- Kantonsspital Baden — Baden, Switzerland
- Kantonsspital Graubünden Medizin Onkologie — Chur, Switzerland
- Kantonsspital St. Gallen — Sankt Gallen, Switzerland
- Kantonsspital Winterthur — Winterthur, Switzerland
- UniversitätsSpital Zürich — Zurich, Switzerland
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.