Reversing Glucose and Lipid-mediated Vascular Dysfunction

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Blood Pressure, Hypertension

In brief

The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure.

Key facts

Study ID

NCT04832009

Run by

University of Kansas Medical Center

People needed

46

Starts

2022-05-09

Expected to finish

2027-08-01

Last updated by the study team

2025-06-05

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Lean: BMI < 25 kg/m
• Normal insulin sensitivity: (calculation based on fasting glucose and insulin concentrations in blood)
• Middle-aged: 18-79 years
• Blood pressure: < 140 (systolic) and < 90 mmHg (diastolic
• Weight stable (+/- 5 lbs) for the previous 3 months
• Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior.
• Able and willing to provide written informed consent

You may not qualify if…

• Diabetes mellitus Type I or Type II: fasting glucose < 126 mg/dL and/or HbA1c < 6.5%
• Current smoker or History of smoking in the past 3 months.
• Hyperlipidemia: Fasting triglycerides < 250 mg/dL
• Hypertension: >130/80 mmHg
• History of heart disease (e.g., myocardial infarction, stent, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)
• History of vascular disease (e.g., bypass, stroke)

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States (enrolling)

Full record on ClinicalTrials.gov

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