Hypothyroidism After the TAVI Procedure in Elderly Patients

Recruiting now · Not applicable

Conditions studied: Hypothyroidism, TAVI

In brief

Aortic stenosis is highly prevalent in advancing age. The prognosis of this disease has dramatically changed with the surgical replacement of the aortic valve and the trans catheter aortic valve re-placement (TAVI). The TAVI procedure is also successful in octogenarians and frail patients. However, the evaluation before the TAVI procedure requires a high dosage of iodinated contrast agent with, consequently, an increased risk for thyroid dysfunction. The primary endpoint of this study is to assess, prospectively, the incidence and the predictive factors (underlying thyroid disease, medication, food preservative, topical antiseptics) of hypothyroidism after a TAVI procedure. The secondary endpoint is the influence of the occurrence of hypothyroidism after the TAVI procedure on the geriatric assessment.

Key facts

Study ID

NCT04831957

Run by

Universitair Ziekenhuis Brussel

People needed

20

Starts

2021-07-26

Expected to finish

2050-12-31

Last updated by the study team

2024-12-09

Who can join

Age: 70 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of signed and dated, written Informed Consent prior to any study specific proce-dures
• Patient: males and females must be ≥ 70 years old
• Patients who will undergo a TAVI procedure

You may not qualify if…

• - No obtained signed, dated and written Informed Consent.
• Known thyroid dysfunction (for example: Basedow, Hashimoto,...)
• Patients receiving any of the following: Lithium, Strumazol or a recent treatment of radio-Iode

Where it is running

• UZ brussel — Brussels, Belgium (enrolling)

Full record on ClinicalTrials.gov

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