The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation
Running, not enrolling · Phase 4 · Has a placebo group
Conditions studied: Healthy
In brief
the purpose of this experiment is to determine if acute melatonin supplementation alters central and peripheral cardiovascular responses to a cold pressor test at rest and during dynamic exercise.
Key facts
- Study ID
- NCT04831398
- Run by
- University of Oklahoma
- People needed
- 100
- Starts
- 2023-01-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-05-05
Who can join
Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy men and women
- Women must be premenopausal with a regular menstrual cycle (26-30 days)
You may not qualify if…
- History of autonomic dysfunction
- Cardiovascular diseases
- Diabetes
- Tobacco/nicotine use
- Systolic Pressure >= 130 mmHg
- Diastolic Pressure >= 85 mmHg
- Regular melatonin use >= 1 use/week
- Allergy to melatonin
- Cardiometabolic medication use (e.g. anti-hypertensives, insulin-sensitizing, statins)
- Sex hormone replacement medical use (e.g. testosterone, estrogen, progesterone)
- Pregnancy
Where it is running
- Department of Health and Exercise Science — Norman, Oklahoma, United States
Full record on ClinicalTrials.gov
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