Study Evaluating the Effect of Food on the Pharmacokinetics of Palovarotene and the Effect of Palovarotene on the Pharmacokinetics of the CYP3A4 Substrate Midazolam in Two Cohorts of Healthy Adult Subjects

Completed · Phase 1

Conditions studied: Fibrodysplasia Ossificans Progressiva

In brief

Study to evaluate the effect of food and the effect of swallowing capsule whole versus sprinkling on apple sauce on the pharmacokinetics (PK)/bioavailability of palovarotene, and evaluate the effect of palovarotene on the PK of the CYP3A4 substrate midazolam.

Key facts

Study ID
NCT04829773
Run by
Clementia Pharmaceuticals Inc.
People needed
48
Starts
2019-01-03
Expected to finish
2019-03-29
Last updated by the study team
2021-04-02

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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