Alcohol Induced de Novo Lipogenesis in Women

Running, not enrolling · Not applicable

Conditions studied: Liver Metabolism

In brief

The study is cross-sectional is design. In the first Aim of this study, 5 women and 5 men will be asked to consume 2g/kg of \[2H\]water (a.k.a. deuterium oxide or heavy water) which incorporates 2H tracers into newly synthesized fatty acids and triglycerides. Deuterated water is not radioactive and has a long history of application in human studies. Researchers will collect blood samples 2 hours before and 5 hours after the participants consume 20 grams of alcohol as vodka to measure alcohol induced hepatic de novo lipogenesis (DNL) in both men in women. In addition, for Aim 2 researchers will recruit an additional 10 women who will be randomized into one of two groups who will consume a beverage containing vodka and sucrose, or sucrose alone. Aim 2 will be identical to the experimental scheme in Aim 2 in order to determine if sucrose enhances the effects of vodka on hepatic DNL.

Key facts

Study ID

NCT04829110

Run by

University of Texas Southwestern Medical Center

People needed

27

Starts

2021-11-11

Expected to finish

2027-03-31

Last updated by the study team

2026-05-07

Who can join

Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or Female
• Ages 21 - 45
• Healthy
• Light to moderate alcohol consumption (≤1 drink a day (\~14g) in women and ≤2 drinks a day (\~28 g) in men)
• BMI between 18.5-29.9
• Normal Nutritional Status
• Ability to speak and understand English

You may not qualify if…

• BMI >29.9
• Comorbid conditions
• Any regular medications, except Oral Contraceptives
• Pregnant or Breastfeeding
• Regular exercise above activities of daily living

Where it is running

• School of Health Professions at UTSW — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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