Directional Versus Nondirectional DBS for ET

Recruiting now · Not applicable

Conditions studied: Essential Tremor

In brief

This will be a single center (OHSU) proof of concept trial to demonstrate that directional deep brain stimulation (DBS) creates a larger therapeutic window for the treatment of essential tremor (ET), effectively treats ET, and minimizes effects on speech, gait and balance compared to nondirectional DBS.

Key facts

Study ID

NCT04828798

Run by

Oregon Health and Science University

People needed

24

Starts

2021-04-01

Expected to finish

2029-10-01

Last updated by the study team

2025-10-30

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A tremor syndrome of bilateral upper limb action tremor with at least 3 years' duration

You may not qualify if…

• Patients who have decided not to receive DBS for control of their medication-refractory essential tremor.
• Patients with secondary tremor (ie not Essential Tremor), such as side effects from medications, secondary to another identified neurologic disease (eg multiple sclerosis, -----Parkinson's disease, dystonia).
• Prior history of deep brain stimulation.
• Prior history of thalamotomy.
• A history or signs of dystonia, ataxia or parkinsonism.
• Task specific tremor.
• Orthostatic tremor.
• Patients with cardiac pacemakers, defibrillators, or neurostimulators.
• Patients who require MRI, ECT, rTMS, or diathermy.
• Subjects with other type of neurological disease or injury.

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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