Prospective Study of Pregnancy in Women With Cystic Fibrosis

Running, not enrolling

Conditions studied: Pregnancy Related, Cystic Fibrosis

In brief

In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators.

Key facts

Study ID

NCT04828382

Run by

Amalia Magaret

People needed

285

Starts

2021-09-30

Expected to finish

2027-06-30

Last updated by the study team

2025-11-03

Who can join

Age: 16 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Pregnant, intending to continue pregnancy, enrolled in the Cystic Fibrosis Foundation Patient Registry (CFFPR)

You may not qualify if…

• None

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• University of California San Diego — La Jolla, California, United States
• National Jewish Health — Denver, Colorado, United States
• University of Florida — Gainesville, Florida, United States
• Joe DiMaggio Children's Hospital — Hollywood, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Saint Luke's Cystic Fibrosis Center of Idaho — Boise, Idaho, United States
• Indiana University Medical Center — Indianapolis, Indiana, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Kentucky — Lexington, Kentucky, United States
• Tulane University — New Orleans, Louisiana, United States
• John Hopkins Hospital — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Boston Children's Hospital, Brigham & Women's Hospital — Boston, Massachusetts, United States
• University of Michigan Health System — Ann Arbor, Michigan, United States
• Helen DeVos Children's Hospital — Grand Rapids, Michigan, United States
• The Minnesota Cystic Fibrosis Center — Minneapolis, Minnesota, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• The Cystic Fibrosis Center of Western New York — Buffalo, New York, United States
• Columbia University Cystic Fibrosis Program — New York, New York, United States
• University of Rochester Medical Center Strong Memorial — Rochester, New York, United States
• SUNY Upstate Medical University — Syracuse, New York, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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