Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)

Completed

Conditions studied: Aortic Stenosis, Aortic Valve Stenosis

In brief

The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.

Key facts

Study ID

NCT04827238

Run by

University of British Columbia

People needed

49

Starts

2021-08-30

Expected to finish

2025-06-20

Last updated by the study team

2025-07-24

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Echocardiographic transaortic mean gradient ≥ 20mmHg OR VARC-3 criteria for ≥ moderate hemodynamic valve deterioration post TAVR on any TTE > 1 month post-TAVR
• Consensus by the Heart Team that the patient is suitable for Standardized Invasive Hemodynamics (SIH).

You may not qualify if…

• CT demonstrating leaflet thrombosis or hypoattenuated leaflet thickening (HALT)

Where it is running

• PIMA Heart Centre — Tucson, Arizona, United States
• Tenet Health — Boca Raton, Florida, United States
• eCommunity — Indianapolis, Indiana, United States
• Community Hospital — Munster, Indiana, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• William Beaumont Hospital — Southfield, Michigan, United States
• Vancouver General Hospital — Vancouver, British Columbia, Canada
• St. Paul's Hospital — Vancouver, British Columbia, Canada
• McMaster University — Hamilton, Ontario, Canada

Full record on ClinicalTrials.gov

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