A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Non-obstructive Hypertrophic Cardiomyopathy Trial

Completed · Phase 2 · Has a placebo group

Conditions studied: Non-obstructive Hypertrophic Cardiomyopathy

In brief

The purpose of this study is to assess the safety, tolerability, and potential efficacy of IMB-1018972 in patients with non-obstructive HCM.

Key facts

Study ID

NCT04826185

Run by

Imbria Pharmaceuticals, Inc.

People needed

67

Starts

2021-06-14

Expected to finish

2023-09-18

Last updated by the study team

2024-04-23

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Hypertrophic Cardiomyopathy consistent with current US and European guidelines
• Ability to perform an upright treadmill cardiopulmonary exercise test
• Agreement to abide by contraceptive requirements

You may not qualify if…

• Clinically significant concurrent condition which could prevent the patient from performing any of the protocol-specified assessments, represent a safety concern if the patient participates in the trial or could confound trial assessments of safety or tolerability
• Women who are pregnant, planning to become pregnant or lactating
• Participation in another clinical study involving a test product or invasive medical device within 28 days (or within 5 elimination half-lives of the respective test product, whichever is longer), prior to first dosing

Where it is running

• Imbria Investigational Site — La Jolla, California, United States
• Imbria Investigational Site — Los Angeles, California, United States
• Imbria Investigational Site — San Francisco, California, United States
• Imbria Investigational Site — Chicago, Illinois, United States
• Imbria Investigational Site — Boston, Massachusetts, United States
• Imbria Investigational Site — Burlington, Massachusetts, United States
• Imbria Investigational Site — St Louis, Missouri, United States
• Imbria Investigational Site — Morristown, New Jersey, United States
• Imbria Investigational Site — New York, New York, United States
• Imbria Investigational Site — Charlotte, North Carolina, United States
• Imbria Investigational Site — Portland, Oregon, United States
• Imbria Investigational Site — Houston, Texas, United States
• Imbria Investigational Site — Salt Lake City, Utah, United States
• Imbria Investigational Site — Oxford, United Kingdom

Full record on ClinicalTrials.gov

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