Persona Revision Knee System Outcomes

Recruiting now

Conditions studied: Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis

In brief

The study will evaluate the performance, clinical benefits and safety of the Persona Revision Knee System in patients who have received primary or revision total knee arthroplasty (TKA) treatment. This will be done using a multicenter, single-arm, consecutive series, retrospective cohort study with prospective follow-up.

Key facts

Study ID

NCT04821154

Run by

Zimmer Biomet

People needed

380

Starts

2021-06-14

Expected to finish

2033-12-31

Last updated by the study team

2026-07-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female of at least 18 years of age at the time of screening.
• Signed an institutional review board approved informed consent.
• Willingness and ability to comply with the study procedures and visit schedules and ability to understand and follow oral and written post-operative care instructions.
• Previous medical diagnosis/ history of at least one of the following conditions requiring treatment using the Persona Revision Knee System within a pre-specified study variant configuration (cohort), in accordance with the instructions for use (IFU):
• Rheumatoid arthritis, osteoarthritis, traumatic arthritis or polyarthritis
• Collagen disorders, and/or avascular necrosis of the femoral condyle
• Post-traumatic loss of joint configuration, particularly when there is patellofemoral erosion, dysfunction or prior patellectomy
• Moderate valgus, varus, or flexion deformities
• The salvage of previously failed surgical attempts or for a knee in which satisfactory stability in flexion cannot be obtained at the time of surgery
• A pre-operative Knee Society Knee Score (objective assessment) ≤ 80.

You may not qualify if…

• Presence of clinically observed active or suspected latent infection in the affected joint at the time of procedure.
• Presence of of local/systemic/distant focal infection that may affect or hematogenously spread to the prosthetic joint.
• Skeletal immaturity or insufficient bone stock on femoral or tibial surfaces which cannot provide adequate support and/or fixation to the prosthesis.
• Diagnosed with neuropathic arthropathy, osteoporosis, or any loss of musculature or neuromuscular disease that compromises the affected limb.
• Presence of a stable, painless arthrodesis in a satisfactory functional position in the affected joint.
• Severe instability of the affected joint secondary to the absence of collateral ligament integrity.
• Diagnosis of rheumatoid arthritis in conjunction with any of the following at the time of screening:
• An ulcer of the skin
• History of recurrent breakdown of the skin
• Use of steroids
• Patient requires simultaneous bilateral knee surgery for treatment of diagnosed condition.
• Pregnant or women planning to become pregnant during the time they will be participating in the study.
• Any documented clinically significant degree of cognitive impairment or other condition, finding, or psychiatric illness at screening which, in the opinion of the Investigator, could compromise patient safety or interfere with the assessment of the safety and treatment effects of the study procedure.
• Any patient who is institutionalized, or with a known drug or alcohol dependence currently or within the last year.

Where it is running

• Advanced Orthopaedic Specialists — Fayetteville, Arkansas, United States (enrolling)
• Bowen Hefley Orthopedics — Little Rock, Arkansas, United States (enrolling)
• Jeff Yergler, LLC — Granger, Indiana, United States (enrolling)
• Ascension Providence Rochester Hospital — Rochester, Michigan, United States (enrolling)
• Michigan Orthopaedic Surgeons, PLLC — Southfield, Michigan, United States (enrolling)
• Orthopaedic Research Institute of New Jersey — Chester, New Jersey, United States (enrolling)
• The Cleveland Clinic Foundation — Cleveland, Ohio, United States (enrolling)
• Orthopedic Surgeons of Wisconsin, SC — Wauwatosa, Wisconsin, United States
• ROC Orthopedics — Oregon City, Oregon, United States
• TRIA Orthopaedic Center Research Institute — Bloomington, Minnesota, United States
• Thomas Aleto MD, PC — Columbia, Missouri, United States
• Community Foundation Medical Group — Fresno, California, United States
• Cornerstone Orthopaedics & Sports Medicine — Superior, Colorado, United States
• Orthopaedic Associates, Inc. — Evansville, Indiana, United States
• Penn Medicine/ Lancaster General Health — Lancaster, Pennsylvania, United States
• Arthroplasty Foundation Inc. — Louisville, Kentucky, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.