Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences

Recruiting now · Not applicable

Conditions studied: Multiple Sclerosis (MS)

In brief

This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the additional clinical value of this sequence in clinical settings.

Key facts

Study ID

NCT04819737

Run by

University Hospital, Basel, Switzerland

People needed

10

Starts

2022-07-18

Expected to finish

2027-12-01

Last updated by the study team

2026-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of multiple sclerosis according to established international criteria
• Steroid free period: > 4 weeks
• Participation in the Swiss MS Cohort (SMSC) study

You may not qualify if…

• . History of severe (other) neurological, internal or psychiatric disease with SC affection
• MRI-related exclusion criteria (questionnaire):
• Paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the SC)
• Pacemaker
• Claustrophobia
• Pregnancy, lactation
• Known hypersensitivity to gadolinium-based contrast media

Where it is running

• University Hospital Basel, Department of Neurology — Basel, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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