Prediction of Outcomes After Surgery for Unruptured Intracranial Aneurysms

Status unconfirmed

Conditions studied: Aneurysm, Brain

In brief

Accurate preoperative identification of patients at high risk for adverse outcomes would be clinically advantageous, as it would allow enhanced resource preparation, better surgical decision-making, enhanced patient education and informed consent, and potentially even modification of certain modifiable risk factors. The aim of the Prediction of adverse events after microsurgery for intracranial unruptured aneurysms (PRAEMIUM) study is therefore to develop and externally validate a clinically applicable, robust ML-based prediction tool based on multicenter data from a range of international centers.

Key facts

Study ID

NCT04819074

Run by

University of Zurich

People needed

4000

Starts

2021-05-20

Expected to finish

2022-10-01

Last updated by the study team

2021-12-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (18 or older)
• Undergone microsurgical treatment for unruptured intracranial aneurysm
• Patients with prior SAH may only be included when surgical treatment occurred at least 4 weeks after ictus.
• Treated from January 1st 2010 onwards

You may not qualify if…

• No specific exclusion criteria

Where it is running

• University Hospital Zurich — Zurich, Switzerland (enrolling)
• UCLA — Los Angeles, California, United States
• UCSF — San Francisco, California, United States
• Stanford University — Stanford, California, United States
• Emory University Hospital — Atlanta, Georgia, United States
• University of Illinois — Chicago, Illinois, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• North Shore University Hospital — Manhasset, New York, United States
• University of Wisconsin — Madison, Wisconsin, United States
• Royal Melbourne Hospital — Melbourne, Australia
• Macquarie University — Sydney, Australia
• Innsbruck University — Innsbruck, Austria
• Linz Kepler Klinikum — Linz, Austria
• Prague University — Prague, Czechia
• Charité Univesitätsmedizin — Berlin, Germany
• University of Cologne — Cologne, Germany
• Dresden Uniklinikum — Dresden, Germany
• Barrow Neurological Institute — Phoenix, Arizona, United States
• Frankfurt University — Frankfurt, Germany
• Universitätsmedizin Göttingen — Göttingen, Germany
• Unimedizin Mainz — Mainz, Germany
• University of Florence - Careggi — Florence, Italy
• University of Genoa — Genoa, Italy
• University of Messina — Messina, Italy

Full record on ClinicalTrials.gov

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