Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments

Recruiting now

Conditions studied: Amyotrophic Lateral Sclerosis

In brief

The aim of this project is to analyze the macrophage transcriptome and protein markers of Amyotrophic Lateral Sclerosis (ALS) patients compared to controls (non-affected individuals, patients with other motor impairments) and asymptomatic ALS gene carriers, to find new pathways for therapeutic targets and disease biomarkers.

Key facts

Study ID

NCT04816227

Run by

Institut National de la Santé Et de la Recherche Médicale, France

People needed

180

Starts

2021-09-29

Expected to finish

2027-09-01

Last updated by the study team

2026-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Agree to participate in this research and have signed an informed consent
• Be able to understand the objectives and procedures of the study
• Be affiliated to French social security or equivalent
• Meet one of the criteria below:
• (i) Be affected by Amyotrophic Lateral Sclerosis (ALS) definite, probable or possible (El Escorial criteria) sporadic SALS (no known history in the family) or familial FALS (at least one other member of the family affected), (ii) not being affected by ALS but having a close relative who has or has been diagnosed with ALS and has or is a carrier of a known mutation causing ALS and has consented to a genetic analysis, (iii) Have a motor impairment including the following pathologies: Motor neuropathy, myopathy, Myositis, Spastic paraplegia, Cram / fasciculation syndrome, Chronic inflammatory polyradiculitis, somatization disorder, Anterior spinal artery syndrome, encephalitis, myelitis, Peroneal neuropathy, cervical myelopathy with radiculopathy, spinocerebellar ataxia, Kennedy disease, Spinal atrophy, Hereditary distal motor neuropathy.
• (iv) be accompanying a person with ALS or other motor impairment that is followed by one of the doctors from the ALS referral center at the Pitié-Salpêtrière hospital or by a neurologist from the neurophysiology department at the Pitié-Salpêtrière hospital.

You may not qualify if…

• Be subjected to a legal protection measure (safeguard of justice, curatorship or guardianship)
• Refusing to participate in the study
• Whose condition, in the opinion of the doctor, is incompatible with blood draw or participation in research
• Being pregnant or breastfeeding

Where it is running

• Département de Neurologie, Hôpital de la Pitié-Salpêtrière — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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