Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA

Completed · Not applicable

Conditions studied: Chronic Post-Surgical Pain

In brief

A significant number of patients develop chronic post-surgical pain (CPSP) following knee replacement surgery. Proposed is the testing of a novel computer-assisted behavioral intervention integrating motivational interviewing in the 4 weeks prior to surgery to address the risk factors for CPSP, with the expectation that severity of post-op pain and the incidence of CPSP will be reduced.

Key facts

Study ID

NCT04814992

Run by

University of Pennsylvania

People needed

54

Starts

2020-10-01

Expected to finish

2023-12-31

Last updated by the study team

2024-10-17

Who can join

Age: 22 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and females, age > 21 years
• Chronic non-malignant pain of at least 3 months duration
• Morphine equivalent daily dose (MEDD) > 40 milligrams for at least 3 months
• Able to enroll at least 4 weeks prior to planned surgery
• Able to speak, read and comprehend in English at the 6th grade or higher proficiency

You may not qualify if…

• Pain of malignant origin
• Current or past history of opioid use disorder (including those on medication-assisted therapy)
• Revision of TKA
• Comorbid CNS disease such as dementia, HIV, psychosis, poorly controlled bipolar disorder or any condition interfering with informed consent

Where it is running

• Penn Medicine University City — Philadelphia, Pennsylvania, United States
• Penn Presbyterian Medical Center — Philadelphia, Pennsylvania, United States
• Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
• Penn Medicine Radnor — Radnor, Pennsylvania, United States

Full record on ClinicalTrials.gov

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