Treatment and Duration Effect of Pentosan Polysulfate Sodium (PPS) in Participants With Knee Osteoarthritis Pain

Completed · Has a placebo group

Conditions studied: Osteoarthritis, Knee

In brief

The purpose of this study is to measure the duration of treatment effect with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with placebo in adult participants with knee osteoarthritis (OA) pain. The study duration will be up to 34 weeks. Participants who completed pDay 162 of Study PARA\_OA\_002 (i.e. did not discontinue/withdraw prematurely from the parent study) will be invited to participate.

Key facts

Study ID

NCT04814719

Run by

Paradigm Biopharmaceuticals Ltd.

People needed

133

Starts

2023-06-24

Expected to finish

2024-12-24

Last updated by the study team

2025-07-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants who completed Day 168 of Study PARA_OA_002 (ie, did not discontinue/withdrew prematurely from the parent study).
• Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.

You may not qualify if…

• An employee of the Sponsor, clinical research organisations or research site personnel directly affiliated with this study or their immediate family members defined as a spouse, parent, sibling, or child, whether biological or legally adopted.

Where it is running

• Northwestern University Feinberg School of Medicine — Chicago, Illinois, United States
• Emeritus Research — Camberwell, Victoria, Australia

Full record on ClinicalTrials.gov

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