Patient-centered Treatment of Anxiety After Low-Risk Chest Pain in the Emergency Room

Status unconfirmed · Not applicable

Conditions studied: Generalized Anxiety Disorder, Chest Pain, Panic

In brief

The goal of this research is to compare the benefits and risks of three anxiety treatments that are pragmatic, graduated in the level of resource intensity, and have demonstrated efficacy and feasibility for real world adoption.

Key facts

Study ID

NCT04811521

Run by

Indiana University

People needed

375

Starts

2021-04-01

Expected to finish

2025-08-17

Last updated by the study team

2024-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult emergency department (ED) patients (≥18yoa) presenting to the ED
• Within 1 week of ED presentation if discharged at time of screening.
• Chief complaint of chest pain or similar chief complaint leading to a standard of care diagnostic protocol to rule out possible acute coronary syndrome.
• HEART Score of 0-3 indicating Major Adverse Cardiac Events (MACE) risk equivalent to ≤2%
• "Functionally" low risk status - (moderate HEART score of 4-6) plus diagnostic protocol evaluation with at least two serial normal troponins spaced at least six hours apart with or without cardiovascular stress testing in the observation unit.
• Moderate to severe anxiety as defined by a GAD-7 score ≥ 8 or a PHQ panic screener score ≥ 2
• Expected to be discharged from the ED or only undergo observation <24 hours.

You may not qualify if…

• > 1 week from ED discharge
• Traumatic reason for chest pain
• Those admitted to the hospital (inpatient status) as part of their ED presentation (those placed in the observation unit for planned observation less than <24 hours are eligible)
• Active psychosis or behavioral issues requiring psychiatric monitoring or consultation of psychiatry for psychosis, schizophrenia, or suicidal ideation
• Hemodynamic instability as assessed by the treating provider
• Issues likely to affect follow up, including prisoners and homelessness
• Inability to understand and speak English to participate in telehealth therapy sessions and peer support.

Where it is running

• Indiana University Health West Hospital — Avon, Indiana, United States
• Indiana University Health North Hospital — Carmel, Indiana, United States
• Indiana University Health Saxony Hospital — Fishers, Indiana, United States
• Indiana University Health Methodist Hospital — Indianapolis, Indiana, United States
• Indiana University Health Ball Memorial Hosptial — Muncie, Indiana, United States

Full record on ClinicalTrials.gov

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